DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
نویسندگان
چکیده
منابع مشابه
Mechanisms of Recurrent Chromosomal Translocations
Chromosomal translocations frequently involve fusion of the ends of two separate DNA double-stranded breaks (DSBs) at distinct genomic locations. Recurrent chromosomal translocations are found in various cancers. Recently developed high-throughput approaches to clone genome-wide translocations that involve site-specifi c DSBs have provided new insights into mechanisms of chromosomal translocati...
متن کاملrOLE OF cHrOMOsOMaL traNsLOcatIONs IN rEcUrrENt sPONtaNEOUs abOrtION
Received for publication: Apr. 06, 2007. Revised: Sep. 22, 2007. rEZUMat 1 Department of Medical Genetics, 2 Department of Obstetrics and Gynecology, Bega Clinic, Victor Babes University of Medicine and Pharmacy, Timisoara, 3 Department of Obstetrics and Gynecology, Vasile Goldis University, Arad
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The most significant complication of pregnancy is recurrent miscarriage. Numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects. Cytogenetic evaluation of couples with recurrent pregnancy losses is performed on the basis of G-banding technique only after other possible et...
متن کاملMechanisms that promote and suppress chromosomal translocations in lymphocytes.
Recurrent chromosomal translocations are characteristic features of many types of cancers, especially lymphomas and leukemias. Several basic mechanistic factors are required for the generation of most translocations. First, DNA double-strand breaks (DSBs) must be present simultaneously at the two participating loci. Second, the two broken loci must either be in proximity or be moved into proxim...
متن کاملHow does DNA break during chromosomal translocations?
Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia. Although many translocations have been reported in the last four decades, the mechanism by which chromosomes break during a translocation remains largely unknown. In this...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature10909